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Autoimmune Polyglandular Syndrome Type 1: Clinical Features, Diagnostic Pathway, and Modern Management Strategies Introduction Autoimmune Polyglandular Syndrome Type 1 (APS-1), also known as autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy (APECED), is a rare monogenic autoimmune disorder characterized by immune-mediated destruction of multiple endocrine glands and other target organs. Early recognition is critical because timely diagnosis and multidisciplinary management can prevent severe complications, reduce morbidity, and improve quality of life. https://www.marketresearchfuture.com/reports/autoimmune-polyglandular-syndrome-type-1-market-35122 Etiology and Pathogenesis APS-1 results from biallelic mutations in the AIRE (autoimmune regulator) gene. AIRE is crucial for central immune tolerance: it promotes expression of peripheral tissue antigens in the thymus so autoreactive T cells are deleted during development. Typical Clinical Presentation APS-1 most often presents in childhood. The classical triad includes: Chronic mucocutaneous candidiasis (CMC) — often the earliest sign, appearing in infancy or early childhood as persistent or recurrent oral, cutaneous, or nail fungal infections. Hypoparathyroidism — may present with tetany, paresthesias, or seizures due to hypocalcemia. Primary adrenal insufficiency (Addison’s disease) — symptoms include fatigue, weight loss, hyperpigmentation, hypotension, and salt craving. Beyond the triad, patients may develop autoimmune thyroid disease, type 1 diabetes, primary gonadal failure, chronic hepatitis, vitiligo, alopecia, enamel hypoplasia, and gastrointestinal dysfunction. Diagnostic Approach Diagnosis rests on clinical suspicion supported by laboratory and genetic testing. Clinical suspicion: Recurrent mucocutaneous candidiasis plus one or more endocrine abnormalities should trigger evaluation for APS-1. Laboratory assessment: Evaluate serum calcium, phosphorus, parathyroid hormone (PTH), morning cortisol and ACTH, electrolytes, thyroid function tests, blood glucose, and autoantibody panels relevant to presenting organs (e.g., 21-hydroxylase antibodies for adrenal autoimmunity). Genetic testing: Identification of pathogenic AIRE mutations confirms the diagnosis and enables family screening and genetic counseling. Additional testing: Imaging and organ-specific tests (e.g., adrenal imaging, bone density assessments) are guided by clinical features. Management Principles APS-1 requires individualized, multidisciplinary care aimed at replacing deficient hormones, treating infections, managing autoimmune manifestations, and preventing complications. Hormone replacement Adrenal insufficiency: Lifelong glucocorticoid replacement (physiologic dosing) and mineralocorticoid replacement when indicated. Patients must be educated on sick-day dosing and carry medical alert information. Hypoparathyroidism: Calcium and active vitamin D (calcitriol) supplementation to maintain symptomatic control and avoid hypercalciuria; consider recombinant PTH in refractory cases. Thyroid and gonadal failure: Standard replacement therapies (levothyroxine, sex steroid replacement) as clinically indicated. Infection control Chronic mucocutaneous candidiasis: Regular antifungal therapy with azoles; long-term suppression may be necessary. Address predisposing factors and monitor for antifungal resistance. Immunomodulation While hormone replacement and antifungal therapy remain cornerstones, immunosuppressive or immunomodulatory treatments may be considered for severe autoimmune organ involvement (for example, autoimmune hepatitis). Monitoring and prevention Lifelong surveillance by an endocrinologist, dermatologist, dentist (for enamel defects), and other relevant specialists is essential. Prognosis and Quality of Life Prognosis varies with the number and severity of organ systems involved and the timeliness of diagnosis. With appropriate replacement therapies and infection management, many patients maintain good function, but risks include life-threatening adrenal crises, seizures from hypocalcemia, and cumulative organ damage. Practical takeaways for clinicians Maintain a high index of suspicion in children with chronic candidiasis and any endocrine abnormality.

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